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Found 6 Enz. Inhib. hit(s) with Target = 'Epidermal growth factor receptor' and Ligand = 'BDBM50391089'
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  1.23nMAssay Description:TBDMore data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  1.23nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  2nMAssay Description:Inhibition of EGFR using GST-Crk as substrate assessed as phosphorylated Crk level after 20 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  5nMAssay Description:Inhibition of EGFR (unknown origin) assessed as reduction of phosphorylation of Crk incubated for 10 mins in ice with gamma-ATP followed by incubated...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50:  45nMAssay Description:Inhibition of EGFR-mediated intracellular tyrosine phosphorylation in EGF-stimulated human A431 cells after 2.5 hrs by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Betta Pharmaceuticals

US Patent
LigandPNGBDBM50391089(BPI-2009 | CHEMBL2087361 | Conmana | Icotinib | Lc...)
Affinity DataIC50: >1.00E+3nMAssay Description:Kinase Assay Protocol:Bar-coded Corning, low volume NBS, black 384-well plate (Corning Cat. #4514)1. 2.5 μL—4× Test Compound or 100 nL 100×...More data for this Ligand-Target Pair
In DepthDetails US Patent