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Found 9 Enz. Inhib. hit(s) with Target = 'Eukaryotic initiation factor 4A-I' and Ligand = 'BDBM50540861'
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  6.30nMAssay Description:Inhibition of eIF4A1 in human HAP1 cells assessed as reduction in cell proliferation incubated for 72 hrs by CellTiter-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  14nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  92nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataIC50:  218nMAssay Description:Inhibition of eIF4A1 in human MDA-MB-231 cells assessed as inhibition of cellular-translation incubated for 4 hrs by specific tandem sequence motif r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataKd:  9.60E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataKd:  3.19E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataKd:  21nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic initiation factor 4A-I(Homo sapiens (Human))
Inception Therapeutics

Curated by ChEMBL
LigandPNGBDBM50540861(EFT-226 | Eft226 | Zotatifin)
Affinity DataKd:  2.43E+3nMAssay Description:Binding affinity to full length recombinant eIF4A1 (unknown origin) assessed as induction ternary complex formation in presence of AGAGAG by measurin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed