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Found 2 Enz. Inhib. hit(s) with Target = 'Eukaryotic translation initiation factor 4E' and Ligand = 'BDBM451158'
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451158(US10676499, Example 55)
Affinity DataKi:  40nMAssay Description:Dual histidine and Avi tagged human EIF4E (His6-3C-avi-eIF4E) was expressed in 8 L of TB Media. Induction by 0.4 mM IPTG occurred at 2.0 OD600, and c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEukaryotic translation initiation factor 4E(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451158(US10676499, Example 55)
Affinity DataKd:  110nMAssay Description:A subset of compounds was further characterized to determine dissociation constants using thermodynamic (Steady State Affinity) binding analysis.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent