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Found 6 Enz. Inhib. hit(s) with Target = 'Fibroblast growth factor receptor 1' and Ligand = 'BDBM286388'
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Affinity DataIC50:  1.20nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of FGFR1 in HUVEC assessed as reduction in FGF2-induced ERK phosphorylation preincubated for 60 mins followed by FGF2 stimulation for 10 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Affinity DataIC50:  2.30nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Affinity DataIC50:  2.30nMAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Affinity DataIC50:  2.30nMT: 2°CAssay Description:A Caliper-based kinase assay (Caliper Life Sciences, Hopkinton, Mass.) was used to measure inhibition of FGFR family (FGFR1, FGFR2, FGFR3, FGFR4) kin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Principia Biopharma

US Patent
LigandPNGBDBM286388(8-(2-(4-acryloylpiperazin-1-yl)ethyl)-6-(2,6-dichl...)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human FGFR1 using 5-FAM-KKKKEEIYFFF-NH2 as substrate preincubated for 15 mins followed by peptide substrate addition measured after 3 h...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed