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Found 15 Enz. Inhib. hit(s) with Target = 'G-protein coupled receptor 84' and Ligand = 'BDBM50239186'
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  8.37E+3nMAssay Description:Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forsk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Mus musculus)
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  4.27E+3nMAssay Description:Agonist activity at mouse Galphai2-coupled GPR84 expressed in human Flp-In-T-REx-293 cell membrane assessed as stimulation of [35S]GTPgammaS binding ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  2.88E+3nMAssay Description:Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forsk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  252nMAssay Description:Agonist activity at Gi coupled human GPR84 expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation after 15 mins in pres...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  1.64E+3nMAssay Description:Agonist activity at human GPR84 expressed in CHO cells assessed as beta-arrestin recruitment after 90 mins by beta-galactosidase complementation assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  6.28E+3nMAssay Description:Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forsk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  700nMAssay Description:Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP produc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  368nMAssay Description:Positive allosteric modulation of recombinant human GPR84 expressed in CHO cell membranes co-expressing beta-arrestin2 assessed as increase in [3H]PS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  1.00E+3nMAssay Description:Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  1.11E+3nMAssay Description:Agonist activity at recombinant human HA-tagged GPR84 stably expressed in HEK293 cells assessed as stimulation of [35S]GTPgammaS binding measured aft...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  500nMAssay Description:Agonist activity at human N-terminal FLAG-tagged GPR84 receptor stably expressed in CHO cell membranes assessed as stimulation of [35S]GTPgammaS bind...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  1.26E+3nMAssay Description:Agonist activity at recombinant human N-terminal epitope tagged/C-terminal eYFP-fused FLAG-tagged GPR84 expressed in Flp-In TREx 293 cell membranes a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  5.90E+3nMAssay Description:Agonist activity at human Gi1alpha-coupled GPR84 expressed in baculovirus infected Sf9 insect cells assessed as stimulation of [35S]GTPgammaS binding...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
University Of Bonn

Curated by ChEMBL
LigandPNGBDBM50239186(1,1-Bis(3''-Indolyl)Methane | 3,3''-Diindolylmetha...)
Affinity DataEC50:  5.12E+3nMAssay Description:Positive allosteric modulation of Gi coupled human GPR84 expressed in CHO cells assessed as potentiation of decanoic acid-induced inhibition of forsk...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed