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Found 2 Enz. Inhib. hit(s) with Target = 'GTPase KRas [1-169,G12C,C118A]' and Ligand = 'BDBM50517182'
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50517182(CHEMBL4591653 | US11053226, Example 3-1)
Affinity DataIC50:  100nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGTPase KRas [1-169,G12C,C118A](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50517182(CHEMBL4591653 | US11053226, Example 3-1)
Affinity DataIC50:  150nMAssay Description:Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and C118A amino acid substitutions and an N-terminal His-tag, was pre-incubated in a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent