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Found
1
Enz. Inhib. hit(s) with Target = 'GTPase KRas [1-169,G12D]' and Ligand = 'BDBM550336'
Target
GTPase KRas [1-169,G12D]
()
Amgen
US Patent
Ligand
BDBM550336
(4-((2S,5R,M)-4-Acryloyl-2,5-dimethylpiperazin-1-yl...)
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Affinity Data
IC50: 38nM
Assay Description:
The following assay conditions were employed: Coupled Nucleotide Exchange Assay: Purified GDP-bound KRAS protein (aa 1-169), containing both G12C and...
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Target Info
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Ligand Info
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US Patent
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