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Found 3 Enz. Inhib. hit(s) with Target = 'Gag-Pol polyprotein' and Ligand = 'BDBM189342'
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
University of Siena

LigandPNGBDBM189342(RDS1759)
Affinity DataIC50:  7.40E+3nMpH: 7.8Assay Description:The RNase H activity associated with HIV-1 RT was measured in a 100 mL reactionvolume containing Tris·HCl (pH 7.8, 50 mm), MgCl2 (6 mm), dithiothreit...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
University of Siena

LigandPNGBDBM189342(RDS1759)
Affinity DataIC50:  7.50E+3nMpH: 7.8 T: 2°CAssay Description:HIV RT-associated RNase H activity was measured as previously described.[J. Med. Chem. 2014, 57:3223-3234] Briefly, the reaction mixture comprised ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein(Human immunodeficiency virus type 1 group M subtyp...)
University of Siena

LigandPNGBDBM189342(RDS1759)
Affinity DataIC50: >5.00E+4nMpH: 8.1Assay Description:The RNA-dependent DNA polymerase (RDDP) activity associated with HIV-1 RT was measured by use of the Invitrogen EnzCheck Reverse Transcriptase Assay ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed