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Found 7 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM141368'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  0.170nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  0.340nMAssay Description:Transrepression of glucocorticoid receptor in Wistar rat PBMC assessed as inhibition of LPS induced TNF alpha release preincubated for 45 mins follow...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  0.540nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  1.36nMAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 _...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  1.36nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  1.5nMAssay Description:Transrepression of glucocorticoid receptor in PMA-stimulated human ChaGoK1 cells expressing TRE-LacZ construct assessed as inhibition of AP-1 mediate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM141368(US8916600, 2 | US8916600, 3 | US9738632, Example 2)
Affinity DataIC50:  1.60nMpH: 7.4 T: 2°CAssay Description:In the GR radioligand binding assay, test compounds were serially diluted in semi-log steps (10 concentrations) with a final concentration of 10 uM. ...More data for this Ligand-Target Pair
In DepthDetails US Patent