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Found 14 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50107347'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataKi:  1.40nMAssay Description:Binding affinity towards glucocorticoid receptor (GR) by displacing [3H]-DexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataKi:  2.5nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataIC50:  6.90nMAssay Description:Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of transcriptional activation in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Forschungszentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  7.90nMAssay Description:Binding affinity to rat glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  780nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  450nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(RAT)
Forschungszentrum Dresden-Rossendorf

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  48nMAssay Description:Inhibition of conconavalin A stimulated rat splenocyte proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  33nMAssay Description:Transcriptional activation in CV-1 cells expressing human glucocorticoid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  520nMAssay Description:The effective concentration in CV-1 cells for glucocorticoid response element activation (GRE).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  450nMAssay Description:Effective concentration in HepG2 cells transfected with LUC gene (E-sel-Luc).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50107347((+)5-Allyl-10-methoxy-2,2,4-trimethyl-2,5-dihydro-...)
Affinity DataEC50:  13nMAssay Description:Inhibition of dihydrofolate reductase DHFR in Pneumocystis carinii.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed