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Found 4 Enz. Inhib. hit(s) with Target = 'Glucocorticoid receptor' and Ligand = 'BDBM50338303'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338303((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Affinity DataKi:  1nMAssay Description:Displacement of radiolabeled dexamethasone from GRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338303((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Affinity DataIC50:  3.90nMAssay Description:Agonist activity at GR expressed in IL-1beta- and TNFalpha-stimulated HepG2 cells assessed as inhibition of NFKB- or AP-1 mediated E-selectin transcr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338303((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Affinity DataIC50:  16nMAssay Description:Agonist activity at human GR expressed in NHDF cells assessed as inhibition of IL-6 production by ELISA relative to dexamethasoneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50338303((+/-)-(3R,4S)-8-chloro-5,7-difluoro-6-(1H-indol-7-...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at GR expressed in african green monkey CV1 cells transfected with luciferase gene linked to MMTV promoter assessed as induction of ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed