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Found 6 Enz. Inhib. hit(s) with Target = 'Glutamate receptor ionotropic, NMDA 1/2A' and Ligand = 'BDBM50044140'
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-MK801 from human forebrain GluN1/GluN2B expressed in HEK293 cells by at -70 mV holding potential by patch-clamp assayMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataKi:  180nMAssay Description:Displacement of [3H]-MK801 from rat brain GluN1/GluN2A expressed in HEK293 cellsMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Rattus norvegicus (Rat))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of eGFP-tagged rat GluN1-1a/GluN2A transfected in human tsA201 cells assessed as inhibition glutamate-induced current measured at -65 mV h...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataIC50:  1.26E+3nMAssay Description:Inhibition of human recombinant NR1/NR2A receptor expressed in U2OS assessed as change in intracellular calcium level by FLIPR assayMore data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataIC50:  3.31E+3nMpH: 7.6Assay Description:Antagonist activity at NR1/NR2A receptor (unknown origin) expressed in Xenopus laevis oocytes assessed as inhibition of glutamate/glycine-induced cur...More data for this Ligand-Target Pair
TargetGlutamate receptor ionotropic, NMDA 1/2A(Homo sapiens (Human))
University Of Houston

Curated by ChEMBL
LigandPNGBDBM50044140(2-(2-Chloro-phenyl)-2-methylamino-cyclohexanone | ...)
Affinity DataIC50:  6.10E+3nMAssay Description:Inhibition of dexamethasone-induced human NR1-1a/NR2A receptor-mediated excitotoxicity in (S)-glutamate/glycine-stimulated mouse L12-G10 cells assess...More data for this Ligand-Target Pair