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Found 10 Enz. Inhib. hit(s) with Target = 'Glycogen synthase kinase-3 beta' and Ligand = 'BDBM50130725'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataKi:  24nMAssay Description:Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  34nMAssay Description:Inhibition of GSK-3beta (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human recombinant GSK3beta using GSM as substrate incubated for 30 mins by luminescence based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human full length GSK3beta expressed in baculovirus in Sf9 insect cells using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate by ADP-Glo kin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  77nMAssay Description:Inhibition of human recombinant GSK3-beta assessed as [gamma33]ATP transfer to biotinylated CREB-peptide substrate after 1 hr by scintillation counti...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human GSK3betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  90nMAssay Description:Inhibition of GSK3-beta by luminescent assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  104nMAssay Description:Inhibition of recombinant GSK3-betaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataIC50:  380nMAssay Description:Inhibitory activity against human glycogen synthase kinase-3beta (GSK3-beta) at 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50130725(3-(3-Chloro-4-hydroxy-phenylamino)-4-(2-nitro-phen...)
Affinity DataEC50:  239nMAssay Description:Keywords: GSK3beta, dose response, kinase, inhibition, HTS Assay Overview: The glycogen synthase kinase-3 beta (GSK-3b) is a known master regulator f...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay