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Found 5 Enz. Inhib. hit(s) with Target = 'Heat shock protein HSP 90-alpha' and Ligand = 'BDBM15372'
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-meth...)
Affinity DataIC50:  19nMAssay Description:Binding affinity to Hsp90alpha N-terminal ATPase domain by TR-FRET assay based competitive binding assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-meth...)
Affinity DataIC50:  880nMAssay Description:Inhibition of Hsp90alpha ATPase activity by malachite green ATP-ase assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-meth...)
Affinity DataEC50:  350nMAssay Description:Inhibition of Hsp90alpha in human SKBR3 cells assessed as ErbB2 degradation by Western blot analysisMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-meth...)
Affinity DataEC50:  210nMAssay Description:Inhibition of Hsp90alpha in human H1299 cells assessed as HIF-1alpha degradation by luciferase reporter assayMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM15372(3-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-meth...)
Affinity DataEC50:  500nMAssay Description:Inhibition of Hsp90alpha in human SKBR3 cells assessed as up-regulation of HSP70 protein by Western blot analysisMore data for this Ligand-Target Pair