Compile Data Set for Download or QSAR
Report error Found 3 Enz. Inhib. hit(s) with Target = 'Heat shock protein HSP 90-beta' and Ligand = 'BDBM31044'
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31044(1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...)
Affinity DataKd:  308nMpH: 8.0Assay Description:A fluorescence polarization (FP) assay monitor the fluorescein-labeled C-terminal Hsp90 peptide-TPRA interaction. FP assay will also confirm binding...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31044(1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...)
Affinity DataKd:  365nMAssay Description:AlphaScreen technology based high-throughput (ALPHA) assay is used to identify inhibitors of Hsp90-TPR2A interaction.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed
TargetHeat shock protein HSP 90-beta(Human)
Yale University

LigandPNGBDBM31044(1-ethyl-6-methyl-3-thiophen-2-yl-pyrimido[5,4-e][1...)
Affinity DataEC50:  1.21E+3nMT: 2°CAssay Description:Cell assay using BT474, SKBR3 and MCF-12F cell lines measured by WST-1 colorimetric cell proliferation assay.More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/1/2011
Entry Details Article
PubMed