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Found 2 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 1' and Ligand = 'BDBM27769'
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM27769(N-(2-amino-5-phenylphenyl)-4-[(pyridin-4-ylamino)m...)
Affinity DataIC50:  10nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM27769(N-(2-amino-5-phenylphenyl)-4-[(pyridin-4-ylamino)m...)
Affinity DataIC50:  10nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed