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Found 9 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 1' and Ligand = 'BDBM50322422'
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  10nMAssay Description:Inhibition of recombinant full-length HDAC1 (unknown origin) using MAZ1600/MAZ1675 as substrate assessed as release of 7 amino-4-methylcoumarin measu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  11nMAssay Description:Inhibition of HDAC1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  11.4nMAssay Description:Inhibition of human recombinant HDAC1 after 15 mins by fluorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human HDAC1 using Ac-Lys-Tyr-Lys(epsilon-acetyl)-AMC as substrate after 24 hrs by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  61nMAssay Description:Inhibition of recombinant HDAC1 (unknown origin) incubated for 15 mins before substrate addition and measured after 30 to 45 mins by HDAC-Glo substra...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human HDAC1 after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  146nMAssay Description:Inhibition of C-terminal His-tagged and C-terminal FLAG-tagged full length human recombinant HDAC1 expressed in baculovirus expression system using f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  228nMAssay Description:Inhibition of recombinant full length C-terminal FLAG/His-tagged human HDAC1 expressed in baculovirus infected Sf9 cells using Ac-peptide-AMC as subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Colorado State University

Curated by ChEMBL
LigandPNGBDBM50322422(CHEMBL1173445 | Largazole)
Affinity DataIC50:  2.33E+3nMAssay Description:Inhibition of full length human recombinant KDAC1 using fluorophore-conjugated substrate measured as fluorigenic release of 7-amino-4-methylcoumarin ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed