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Found 11 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 11' and Ligand = 'BDBM50439674'
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+3nMAssay Description:IC50 measurements were conducted by BPS Biosciences (Table 1) or by Nanosyn (Table 1A) with an established fluorescence assay. More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of full length human recombinant HDAC11 expressed in Sf9 baculovirus system using FAM-labeled acetylated peptide as substrate by measuring...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant full length HDAC11 (unknown origin) expressed in insect Sf9 cells by EMSA analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant full length human HDAC11 expressed in SF9 baculovirus using FAM- labelled acetylated peptide as substrate measured by Elect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of human HDAC11 using fluorogenic HDAC substrate incubated for 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+3nMAssay Description:Inhibition of recombinant human HDAC11 using fluorogenic HDAC substrate class 2a incubated for 30 mins by fluorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HDAC11 (unknown origin) measured by fluorescence based assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of HDAC11 (unknown origin) using fluorescent peptide substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+4nMAssay Description:PGE-2 (EP1 subtype) antagonistic activity as PGE2-stimulated guinea pig ileum muscle strip assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal Strep2-tagged HDAC11 (1 to 347 residues) expressed in baculovirus infected insect cells using Boc-Lys(TFA)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
The General Hospital

US Patent
LigandPNGBDBM50439674(RICOLINOSTAT | US10858323, Compound 2 | US11207431...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of recombinant HDAC11 (unknown origin) using AMC labeled AC-peptide as substrate incubated for 1 hr by fluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed