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Found 5 Enz. Inhib. hit(s) with Target = 'Histone deacetylase 4' and Ligand = 'BDBM162846'
TargetHistone deacetylase 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  0.970nMpH: 8.0 T: 2°CAssay Description:Human recombinant HDAC4 was expressed in full length form (aa 2-1084) in Sf9 insect cells (obtained from ATCC) using baculovirus generated with Bac-t...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistone deacetylase 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  3nMAssay Description:Inhibition of HDAC4 (unknown origin) using Boc Lys(TFA) as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant HDAC4 (unknown origin) using Boc-Lys(TFA)-AMC as substrate by fluorescence based plate reader assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM162846(US9056843, 137)
Affinity DataIC50:  20nMAssay Description:Inhibition of Class 2A HDAC4 in human Jurkat E6.1 cells using Boc-Lys-(TFA)-AMC as substrate by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM162846(US9056843, 137)
Affinity DataKd:  44nMAssay Description:Binding affinity to immobilized HDAC4 catalytic domain (unknown origin) by surface plasmon resonance assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed