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Found 4 Enz. Inhib. hit(s) with Target = 'Histone-binding protein RBBP4/Histone-lysine N-methyltransferase EZH2/Polycomb protein EED/Polycomb protein SUZ12/Zinc finger protein AEBP2' and Ligand = 'BDBM347682'
LigandPNGBDBM347682(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: <10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM347682(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50: <10nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM347682(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50:  13nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM347682(N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)met...)
Affinity DataIC50:  20nMAssay Description:Compounds contained herein were evaluated for their ability to inhibit the methyltransferase activity of EZH2 within the PRC2 complex. Human PRC2 com...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent