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Found 6 Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor 1-alpha' and Ligand = 'BDBM50095469'
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50095469((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in human HeLa cells expressing HRE-Luc after 12 hrs by luciferase reporter gene assa...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50095469((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50095469((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of HIF1alpha transcriptional activity in human HeLa cells transfected with HRE-firefly luciferase and cytomegalovirus-promoter expressing ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50095469((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Affinity DataIC50:  9.21E+3nMAssay Description:Inhibition of hypoxia-induced HIF1alpha transcriptional activity in HEK293 cells incubated for 16 hrs by hypoxia response element-driven luciferase r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50095469((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Affinity DataIC50:  1.38E+4nMAssay Description:Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Gakushuin University

Curated by ChEMBL
LigandPNGBDBM50095469((5-(1-benzyl-1H-indazol-3-yl)furan-2-yl)methanol |...)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Sk-Hep1 cells by reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed