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Found 3 Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50545146'
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM50545146(CHEMBL4639448 | US11591301, Compound 21)
Affinity DataIC50:  99nMAssay Description:IDO1 (His-tag) enzyme(BPS Bioscience), L-tryptophan (Sigma), methylene blue (Sigma), Catalase originated from the liver of cattle (Sigma), L-ascorbic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM50545146(CHEMBL4639448 | US11591301, Compound 21)
Affinity DataIC50:  126nMAssay Description:Inhibition of IDO1 (unknown origin) assessed as reduction in kynurenine formation using L-tryptophan as substrate incubated for 60 mins by fluorescen...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Hinova Pharmaceuticals

US Patent
LigandPNGBDBM50545146(CHEMBL4639448 | US11591301, Compound 21)
Affinity DataEC50:  15nMAssay Description:Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells assessed as reduction in kynurenine formation using L-tryptophan as substrate incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed