Compile Data Set for Download or QSAR
Found 1 Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM294326'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Merck Sharp & Dohme Corp

US Patent
LigandPNGBDBM294326(US9586948, Example 45)
Show SMILES Cn1cc(NC(=O)c2cccc(n2)-c2ccnc(NCC3CC3)c2)c(n1)C(=O)NCC1CCS(=O)(=O)C1
Show InChI InChI=1S/C25H29N7O4S/c1-32-14-21(23(31-32)25(34)28-13-17-8-10-37(35,36)15-17)30-24(33)20-4-2-3-19(29-20)18-7-9-26-22(11-18)27-12-16-5-6-16/h2-4,7,9,11,14,16-17H,5-6,8,10,12-13,15H2,1H3,(H,26,27)(H,28,34)(H,30,33)
Affinity DataIC50: 3.62E+3nMpH: 7.2Assay Description:The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid