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Found 8 Enz. Inhib. hit(s) with Target = 'Kappa-type opioid receptor' and Ligand = 'BDBM50474153'
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataKi:  74nMAssay Description:Displacement of [3H]U69,593 from human recombinant kappa opioid receptor expressed in rat RBL cell membranes incubated for 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataKi:  123nMAssay Description:Displacement of [3H]U-69593 from kappa opoid receptor in Dunkin-Hartley guinea pig brain after 1 hr by liquid scintillation spectrometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataKi:  123nMAssay Description:Binding affinity using guinea pig brain membrane preparations, towards Opioid receptor kappa 1 using [3H]- U-69,593 as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Memorial Sloan Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataKi:  131nMAssay Description:Displacement of [125I]-IBNtxA from mouse kappa opioid receptor-1 expressed in CHO cell membranes incubated for 90 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataKi:  195nMAssay Description:Displacement of [3H]U-69,593 from guinea pig brain kappa opoid receptor after 1 hr by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataKi: >1.00E+3nMAssay Description:Inhibition of kappa opioid receptor in guinea pig brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Mus musculus (Mouse))
Memorial Sloan Kettering Cancer Center

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataIC50:  2.52E+3nMAssay Description:Antagonist activity at mouse kappa opioid receptor-1 expressed in CHO cell membranes assessed as inhibition of U50,488H-induced [35S]GTPgammaS bindin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
Temple University School Of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Affinity DataEC50:  53nMAssay Description:Agonist activity at kappa opioid receptor in guinea pig brain membranes by [35S]-GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed