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Found 3 Enz. Inhib. hit(s) with Target = 'L-lactate dehydrogenase A chain' and Ligand = 'BDBM489090'
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489090(2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrah...)
Affinity DataIC50:  5nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489090(2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrah...)
Affinity DataIC50: <100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489090(2-(5- (cyclopropylmethyl)- 3-(4-fluoro-3- ((tetrah...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed