Compile Data Set for Download or QSAR
maximum 50k data
Found 3 Enz. Inhib. hit(s) with Target = 'L-lactate dehydrogenase A chain' and Ligand = 'BDBM489160'
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489160(2-(3-(3-(tert- butylcarbamoyl)-4- fluorophenyl)-5-...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489160(2-(3-(3-(tert- butylcarbamoyl)-4- fluorophenyl)-5-...)
Affinity DataIC50: <100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
Vanderbilt University

Curated by ChEMBL
LigandPNGBDBM489160(2-(3-(3-(tert- butylcarbamoyl)-4- fluorophenyl)-5-...)
Affinity DataIC50:  1.17E+4nMAssay Description:Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed