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Found 9 Enz. Inhib. hit(s) with Target = 'LIM domain kinase 1' and Ligand = 'BDBM50591082'
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  84nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) expressed in baculovirus infected insect cells using CFL1 as substrate preincu...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  195nMAssay Description:Inhibition of PAK mediated recombinant LIMK1 phosphorylation (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition me...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant LIMK1 (330 to 637 residues) (unknown origin) incubated for 45 mins followed by ATP addition measured after 105 mins by Rapi...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  229nMAssay Description:Inhibition of recombinant LIMK1(unknown origin) expressed in HEK293 cells using NanoGlo substrate incubated for 2 hrs followed by substrate addition ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  238nMAssay Description:Inhibition of recombinant full length LIMK1 (330 to 637 residues) (unknown origin) expressed in HEK293T cells incubated for 2 hrs in presence of trac...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataIC50:  824nMAssay Description:Inhibition of LIMK1 in human HeLa cells lysate incubated for 45 mins by kinobead based pulldown assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataKd:  64nMAssay Description:Binding affinity to recombinant LIMK1 (330 to 637 residues) (unknown origin) expressed in baculovirus infected insect cells assessed as dissociation ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataKd:  682nMAssay Description:Binding affinity to LIMK1 in human HeLa cells assessed as apparent dissociation constant incubated for 45 mins by kinobead based pulldown assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetLIM domain kinase 1(Homo sapiens (Human))
Johann Wolfgang Goethe-University

Curated by ChEMBL
LigandPNGBDBM50591082(CHEMBL4790618)
Affinity DataKd:  120nMAssay Description:Binding affinity to human wild-type full length LIMK1 (M1 to D647 residues) expressed in bacterial expression system assessed as dissociation constan...More data for this Ligand-Target Pair
In DepthDetails PubMed