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Found 3 Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM501810'
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50:  11nMAssay Description:Inhibition of LSD1 (unknown origin) using H3K4me1 substrate by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50: <100nMAssay Description:The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetLysine-specific histone demethylase 1A(Homo sapiens (Human))
Fount Therapeutics

Curated by ChEMBL
LigandPNGBDBM501810(4-[6-(4-amino-piperidin-1-yl)-4- methyl-5-oxo-3-p...)
Affinity DataIC50:  120nMAssay Description:Inhibition of LSD1 in human THP1 cells assessed as induction of cell differentiation by measuring CD11b expression incubated for 96 hrs by FACS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed