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Found 3 Enz. Inhib. hit(s) with Target = 'Lysosomal acid glucosylceramidase' and Ligand = 'BDBM50196532'
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196532(CHEMBL3912910 | US10167270, Compound 6j)
Affinity DataIC50:  3.32E+4nMpH: 5.9Assay Description:Inhibition of synthetic recombinant wild type GCase enzyme velaglucerase alfa (unknown origin) at pH 5.9 preincubated for 5 mins followed by addition...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196532(CHEMBL3912910 | US10167270, Compound 6j)
Affinity DataIC50:  3.32E+4nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetLysosomal acid glucosylceramidase(Homo sapiens (Human))
Northwestern University Feinberg School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50196532(CHEMBL3912910 | US10167270, Compound 6j)
Affinity DataIC50:  3.55E+4nMAssay Description:The enzyme in GCase enzyme activity buffer (25 μL/well) was added to a 384-well black plate. The fluorescent probe 3 (25 nL/well, 50 nM final co...More data for this Ligand-Target Pair
In DepthDetails US Patent