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Found 5 Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4' and Ligand = 'BDBM50225589'
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataKi:  0.5nMAssay Description:Displacement of [12]NDPMSH from human MC4R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Mus musculus)
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataKi:  0.600nMAssay Description:Binding affinity to mouse MC4RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataKi:  540nMAssay Description:Binding affinity to MC5RMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataIC50:  48nMAssay Description:Antagonist activity at MC4R assessed as inhibition of alphaMSH-stimulated cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocortin receptor 4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50225589((4-(1-((3-fluoro-4-methoxybenzylamino)methyl)cyclo...)
Affinity DataEC50:  170nMAssay Description:Agonist activity at MC4R assessed as stimulation of cAMP releaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed