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Found 3 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 2' and Ligand = 'BDBM50343307'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343307(1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  109nMAssay Description:Positive allosteric modulation of rat mGluR2 expressed in HEK293 cells co-expressing Galpha15 G protein assessed as increase in glutamate-induced int...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343307(1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  6.31E+3nMAssay Description:Agonist activity at human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50343307(1-methyl-2-((4-(2-(trifluoromethyl)phenyl)piperidi...)
Affinity DataEC50:  316nMAssay Description:Positive modulation of human mGluR2 expressed in CHO cells co-expressing Ga16 G-protein assessed as glutamate-induced response by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed