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Found 3 Enz. Inhib. hit(s) with Target = 'Metabotropic glutamate receptor 5' and Ligand = 'BDBM50342430'
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342430((R)-cyclobutyl(2-(3-m-tolyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]-M-MPEP from mGluR5 in rat cerebrocortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50342430((R)-cyclobutyl(2-(3-m-tolyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataIC50:  300nMAssay Description:Negative allosteric modulator activity at mGluR5 receptor expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium flux preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
Gedeon Richter

Curated by ChEMBL
LigandPNGBDBM50342430((R)-cyclobutyl(2-(3-m-tolyl-1,2,4-oxadiazol-5-yl)p...)
Affinity DataIC50:  490nMAssay Description:Allosteric modulation of mGluR5 in E17 rat neuronal cultures assessed as inhibition of (S)-3,5-dihydroxyphenylglycine-induced calcium levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed