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Found 3 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 1' and Ligand = 'BDBM157161'
TargetMitogen-activated protein kinase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM157161(US9023865, 5)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mouse ERK2 preincubated for 15 mins followed by addition of IMAP peptide substrate and ATP measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Rattus norvegicus (rat))
Merck

Curated by ChEMBL
LigandPNGBDBM157161(US9023865, 5)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of mouse ERK2 preincubated for 15 mins followed by addition of IMAP peptide substrate and ATP measured after 60 mins by IMAP-FP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1(Mus musculus (Mouse))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM157161(US9023865, 5)
Affinity DataIC50:  0.502nMAssay Description:Activated ERK2 activity was determined in an IMAP-FP assay (Molecular Devices). Using this assay format, the potency (IC50) of each compound was dete...More data for this Ligand-Target Pair
In DepthDetails US Patent