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Found 5 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase 14' and Ligand = 'BDBM15754'
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of p38alpha in hTERT-immortalized human HCA2 cells assessed as decrease in phosphorylated HSP27 level by ELISA in presence of anisomycinMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  250nMAssay Description:Inhibition of p38alpha-induced TNFalpha production in human THP1 cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  400nMAssay Description:Inhibition of p38alpha (unknown origin)-mediated IL1beta production in peripheral mononucleocytesMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  500nMAssay Description:Inhibition of p38alpha (unknown origin)-mediated TNFalpha production in peripheral mononucleocytesMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM15754((2S)-3-(3-{[5-amino-1-(4-fluorophenyl)-1H-pyrazol-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of human recombinant active p38alpha MAP kinase was tested by measuring the incorporation of 33P from gamma-[33P] ATP into myelin basic pr...More data for this Ligand-Target Pair