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Found 5 Enz. Inhib. hit(s) with Target = 'Monoglyceride lipase' and Ligand = 'BDBM50531972'
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataKi:  39nMAssay Description:Competitive inhibition of human recombinant MAGL using 4-NPA as substrate after 30 mins by Michaelis-Menten-based plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant MAGL using 4-NPA as substrate after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataIC50:  81nMAssay Description:Inhibition of human recombinant MAGL using 4-nitrophenylacetate as substrate incubated for 30 mins by microplate reader assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataIC50:  193nMAssay Description:Inhibition of MAGL in human U937 cell homogenates incubated for 5 mins in presence of [1,2,3-3H]2-OG by liquid scintillation spectroscopyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Mus musculus (mouse))
University Of Pisa

Curated by ChEMBL
LigandPNGBDBM50531972(CHEMBL4536045)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of MAGL in mouse brain membranes assessed as reduction in 2-OG hydrolysis preincubated for 15 mins followed by substrate addition and meas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed