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Found 4 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor' and Ligand = 'BDBM50014995'
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataKi:  1.25nM ΔG°:  -50.8kJ/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
The University of Bath

US Patent
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataKi:  1.25nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]-DAMGO from human mu opioid receptor transfected in CHO cells after 60 mins by beta-plate liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50014995(CHEMBL3262090 | US9259422, 13a, R = Ph-BU126 | US9...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human mu opioid receptor transfected in CHO cells assessed as stimulation of [35S]GTPgammaS binding after 60 mins by beta-plate l...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed