BindingDB PrimarySearch

Found 2 Enz. Inhib. hit(s) with Target = 'NPC1-like intracellular cholesterol transporter 1' and Ligand = 'BDBM50371521'

NPC1-like intracellular cholesterol transporter 1(Rattus norvegicus)
Pfizer

Curated by ChEMBL

BDBM50371521(EZETIMIBE)

Ki: 200nMAssay Description:Displacement of [3H]ezetimibe-glucuronide from NPC1L1 in Sprague-Dawley rat brush border membraneMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Purchase ChEBI
DrugBank MCE
PC cid PC sid PDB Similars

Details Article PubMed

NPC1-like intracellular cholesterol transporter 1(Homo sapiens (Human))
The Affiliated Hospital Of Qingdao University

Curated by ChEMBL

BDBM50371521(EZETIMIBE)

IC50: 370nMAssay Description:Inhibition of NPC1L1 (unknown origin) assessed as inhibition of cholesterol cellular uptake by BCA colorimetric assayMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Purchase ChEBI
DrugBank MCE
PC cid PC sid PDB Similars

Details PubMed DrugBank
PDB

3D Structure (crystal)