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Found 4 Enz. Inhib. hit(s) with Target = 'Nuclear receptor ROR-gamma' and Ligand = 'BDBM382537'
TargetNuclear receptor ROR-gamma(Mus musculus)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM382537(US10273259, Example 246 | US10273259, Example 494 ...)
Affinity DataIC50:  23nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Mus musculus)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM382537(US10273259, Example 246 | US10273259, Example 494 ...)
Affinity DataIC50:  46nMAssay Description:The binding of potential ligands to RORγ is measured by competition with [3H]25-hydroxycholesterol (Perkin Elmer NET674250UC) using a scintillat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382537(US10273259, Example 246 | US10273259, Example 494 ...)
Affinity DataEC50:  34nMAssay Description:Inverse agonist activity at RORgammat in human whole blood assessed as IL-17 production by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM382537(US10273259, Example 246 | US10273259, Example 494 ...)
Affinity DataEC50:  21nMAssay Description:Inverse agonist activity at Gal4-fused RORgammat LBD (unknown origin) by reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed