Found 10 Enz. Inhib. hit(s) with Target = 'Orexin/Hypocretin receptor type 1' and Ligand = 'BDBM50384416' TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataKi: 14nMAssay Description:Displacement of [125I]-orexin A from human OX1 receptor expressed in CHO cell membranes after 90 mins by scintillation countingMore data for this Ligand-Target Pair
3D Structure (crystal)TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataKi: 16nMAssay Description:Displacement of [3H]4-(2,6-Difluoro-4-methoxybenzyl)-2-(5,6-dimethoxypyridin-3-yl)-2H-1,2,4-benzothiadiazin-3(4H)-one 1,1-dioxide from human wild-typ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataKi: 18nMAssay Description:Displacement of N6,10-rhodamine green-tagged orexin-A from human OX1 receptor expressed in CHO cells measured after 30 mins by syto62 staining based ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataKi: 28nMAssay Description:Binding affinity to orexin receptor 1 (unknown origin)More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataKi: 48nMAssay Description:Binding affinity to human OXIRMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at OX1 receptor (unknown origin)More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Antagonist activity at OX1 receptor expressed in CHO cells assessed as inhibition of OXA-stimulated intracellular calcium mobilization after 30 mins ...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at OX1 receptor expressed in RD-HGA16 cells assessed as inhibition of orexin A-induced intracellular calcium mobilization after 1...More data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells by Syto62 probe based fluorescence assayMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
University Of Helsinki
Curated by ChEMBL
University Of Helsinki
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Antagonist activity at human OX1R expressed in CHOK1 cells by Syto62 probe based fluorescence assayMore data for this Ligand-Target Pair
