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Found 4 Enz. Inhib. hit(s) with Target = 'P2X purinoceptor 7' and Ligand = 'BDBM296320'
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296320(US10112937, Example 429)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296320(US10112937, Example 429)
Affinity DataIC50:  17.1nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296320(US10112937, Example 429)
Affinity DataIC50:  40nMAssay Description:Antagonist activity at rat recombinant P2X7 expressed in 1321N1 cells assessed as inhibition of BzATP-induced calcium mobilization after 30 mins by c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM296320(US10112937, Example 429)
Affinity DataIC50:  41.6nMpH: 7.4Assay Description:1321N1 cells expressing the recombinant human or rat P2X7 channel was cultured in HyQ DME/(HyClone/Dulbecco's Modified Eagle Medium) high glucose...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent