Found 6 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM15234' TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University Of New York-Esf
Curated by ChEMBL
State University Of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of PI3 kinase p110alpha/p85alpha complexMore data for this Ligand-Target Pair
3D Structure (crystal)TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University Of New York-Esf
Curated by ChEMBL
State University Of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 4.20nMpH: 7.4 T: 2°CAssay Description:Ptdlns 3-kinase enzyme activity was assayed by its converting Ptdlns(4,5)P2 into PtdIns(3,4,5)P3 in the presence of radioactive ATP. After reaction,...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University Of New York-Esf
Curated by ChEMBL
State University Of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of human full-length recombinant p110alpha/p85alpha co-expressed in baculovirus expression system using PIP2:PS lipid as substrate incubat...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University Of New York-Esf
Curated by ChEMBL
State University Of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 11.9nMAssay Description:Inhibition of human recombinant P110alpha/p85alpha using phosphatidyl inositol as substrate after 1 hr by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University Of New York-Esf
Curated by ChEMBL
State University Of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 99nMpH: 7.4 T: 2°CAssay Description:The luminescence-based kinase assay with recombinant phosphatidylinositol 3-kinase (Upstate Cell Signaling Solutions) was used for the determination ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
State University Of New York-Esf
Curated by ChEMBL
State University Of New York-Esf
Curated by ChEMBL
Affinity DataIC50: 1.61E+3nMAssay Description:Inhibition of PI3K p110alpha/p85alpha (unknown origin) by ADP-Glo assayMore data for this Ligand-Target Pair
