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Found 3 Enz. Inhib. hit(s) with Target = 'Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform' and Ligand = 'BDBM315477'
LigandPNGBDBM315477(US10172858, Table 1.1 | US10172858, Table 1.22)
Affinity DataKi:  28nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2 as substrate measured after 30 mins by TR-FRET assayMore data for this Ligand-Target Pair
LigandPNGBDBM315477(US10172858, Table 1.1 | US10172858, Table 1.22)
Affinity DataIC50: >200nMAssay Description:Inhibition of PI3K-alpha (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
LigandPNGBDBM315477(US10172858, Table 1.1 | US10172858, Table 1.22)
Affinity DataKd:  15nMAssay Description:Inhibition of human PI3Kalpha (108 to 1068 residues) expressed in mammalian expression system by KINOMEscan assayMore data for this Ligand-Target Pair