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Found 3 Enz. Inhib. hit(s) with Target = 'Plasma kallikrein' and Ligand = 'BDBM492893'
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(N-((6-amino-2,4- dimethylpyridin-3- yl)methyl)-5-(...)
Affinity DataIC50: <100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(N-((6-amino-2,4- dimethylpyridin-3- yl)methyl)-5-(...)
Affinity DataIC50: <100nMAssay Description:Inhibition of human plasma kallikrein usingPro-Phe-Arg-AMC as substrate incubated for 5 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492893(N-((6-amino-2,4- dimethylpyridin-3- yl)methyl)-5-(...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent