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Found 5 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM139658'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PARP1 by chemiluminescent assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant PARP-1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant PARP1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  2nMAssay Description:Inhibition of recombinant human PARP1 using DNase I-activated herring sperm DNA and [3H]nicotinamide after 2 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
West China Hospital

Curated by ChEMBL
LigandPNGBDBM139658(US8894989, 37)
Affinity DataIC50:  12nMpH: 8.0Assay Description:A convenient method to determine IC50 of a PARP inhibitor compound is a PARP assay using purified recombinant human PARP from Trevigan (Gaithersburg,...More data for this Ligand-Target Pair
In DepthDetails US Patent