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Found 3 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM50438233'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438233(CHEMBL2407988)
Affinity DataIC50:  147nMAssay Description:Inhibition of human PARP1 catalytic activity after 10 mins by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438233(CHEMBL2407988)
Affinity DataEC50:  20nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assay in presence of 100 uM of temozolomideMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50438233(CHEMBL2407988)
Affinity DataEC50:  7.70E+4nMAssay Description:Inhibition of PARP1 in human Jurkat cells assessed as reduction of cell viability after 96 hrs by MTS assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed