Found 9 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-1' and Ligand = 'BDBM27566' TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 10.4nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.23E+3nMAssay Description:Inhibition of recombinant human TNKS1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.50E+3nMAssay Description:An AlphaScreen (Perkin-Elmer) assay was developed in which His-tagged recombinant TANK-1 protein was incubated with biotinylated NAD+ in a 384-well P...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of TNKS1 (unknown origin) using biotin-NAD+ as substrate incubated for 1 hr in the presence of deoxy-oligonucleotide by ELISA analysis rel...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.70E+3nMAssay Description:In order to test the selectivity of substituents on piperazinotriazole ring within the PARP family, the selectivity of compound S3 and positive compo...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of human N-terminal GST-tagged TNKS1 (1001 to 1327 residues) expressed in baculovirus infected sf9 cells using histone as substrate after ...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human TNKS1 (1001 to 1327 residues) expressed in Baculovirus infected Sf9 insect cells using activated DNA as substrate after 1 hr by s...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Shanghai Institute of Material Medica, Chinese Academy of Sciences
US Patent
Affinity DataIC50: >7.00E+4nMAssay Description:Inhibition of human recombinant PARP5a (E1023 to T1327 amino acids) incubated for 4 hrs by fluorescence anisotropy binding assayMore data for this Ligand-Target Pair
