Found 3 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-1' and Ligand = 'BDBM50250875' TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human TNKS1 (1030 to 1317 residues) measured after 20 hrs in presence of NAD+ by fluorescence assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Leibniz-Forschungsinstitut F�R Molekulare Pharmakologie (Fmp)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
