Found 5 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase tankyrase-2' and Ligand = 'BDBM50007583' TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS2 (unknown origin)More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 56nMAssay Description:Inhibition of TNKS-2 in mouse L-Wnt-STF cells assessed as disruption of Wnt signaling after 24 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: 56nMAssay Description:Antagonistic activity against histamine H3 receptor in guinea pig ileumMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
University Of South Australia
Curated by ChEMBL
University Of South Australia
Curated by ChEMBL
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biot...More data for this Ligand-Target Pair
