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Found 7 Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid 5-lipoxygenase' and Ligand = 'BDBM50008950'
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  600nMAssay Description:In vitro inhibition of 5-lipoxygenase in rat (peritoneal assay)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  600nMAssay Description:Iin vitro inhibition of 5-lipoxygenase activity in rat basophil leukemia type 1(RBL1) cell homogenates, (reduction of [14C]-5-HETE formation)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  690nMAssay Description:Evaluated for inhibition of the formation and release of 5-lipoxygenase in isolated guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Sankyo

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human neutrophil 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Tested for inhibition of 5-LO by measuring the reduction of leukotriene B4 (LTB4) in intact basophilic rat leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Centre De Recherches De Vitry

Curated by ChEMBL
LigandPNGBDBM50008950(3-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-dihydr...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibitory activity against 5-lipoxygenase in rat basophilic leukemia cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed