Found 6 Enz. Inhib. hit(s) with Target = 'Polyunsaturated fatty acid lipoxygenase ALOX12' and Ligand = 'BDBM50447175' TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataKi: 350nMAssay Description:Uncompetitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-...More data for this Ligand-Target Pair
3D Structure (crystal)TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataKi: 720nMAssay Description:Competitive inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate assessed as 12-HPETE formation by Henri-Mi...More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of N-terminal His6-tagged human platelet 12-LOX using arachidonic acid as substrate by UV-vis spectrophotometric analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:UV-vis cuvette-based assay.More data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Homo sapiens (Human))
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 360nMAssay Description:Inhibition of wild type human N-terminal His-tagged 12-LOX using arachidonic acid as substrate by UV-Vis spectroscopy analysisMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid lipoxygenase ALOX12(Mus musculus)
National Institutes Of Health
Curated by ChEMBL
National Institutes Of Health
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of 12-LOX in mouse BTC3 cells assessed as inhibition of arachidonic acid/calcium ionophore-induced 12-HETE production after 4 hrs by ELISAMore data for this Ligand-Target Pair
